Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammation01:38

Inflammation

Overview
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin D deficiency and co-morbidities in COVID-19 patients - A fatal relationship?

NFS journal·2025
Same author

Corrigendum to "Vitamin D deficiency and co-morbidities in COVID-19 patients - A fatal relationship?" [NFS Journal 20 (2020) 10-21].

NFS journal·2025
Same author

Obesity, vitamin D deficiency and old age a serious combination with respect to coronavirus disease-2019 severity and outcome.

Current opinion in clinical nutrition and metabolic care·2020
Same author

Climate Change Enhanced Carotenoid Pro-Vitamin A Levels of Selected Plantain Cultivars.

Plants (Basel, Switzerland)·2020
Same author

Validation of the CIMI-Ethiopia Program and Seasonal Variation in Maternal Nutrient Intake in Enset (False Banana) Growing Areas of Southern Ethiopia.

International journal of environmental research and public health·2019
Same author

Dietary Diversity and Anthropometric Status of Mother-Child Pairs from <i>Enset</i> (False Banana) Staple Areas: A Panel Evidence from Southern Ethiopia.

International journal of environmental research and public health·2019

Related Experiment Video

Updated: Jul 9, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

Polyphenols and inflammation: basic interactions.

Hans K Biesalski1

  • 1Department of Biological Chemistry and Nutrition, University Hohenheim, Stuttgart, Germany. biesal@uni-hohenheim.de

Current Opinion in Clinical Nutrition and Metabolic Care
|December 20, 2007
PubMed
Summary
This summary is machine-generated.

Polyphenols, found in fruits and vegetables, show promise in managing inflammation and oxidative stress. Further clinical studies are needed to confirm their therapeutic potential in specific inflammatory conditions.

More Related Videos

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

Related Experiment Videos

Last Updated: Jul 9, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
12:00

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro

Published on: July 5, 2017

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

Area of Science:

  • Nutritional Biochemistry
  • Molecular Biology
  • Immunology

Background:

  • Polyphenols, bioactive compounds from plants, have been investigated for over two decades for their potential health benefits.
  • These compounds are widely studied for their roles in preventing cancer, degenerative diseases, and inflammation.

Purpose of the Study:

  • To review recent scientific literature on the effects of polyphenols on inflammatory cascade modulators.
  • To understand the molecular mechanisms underlying polyphenol interactions with inflammatory pathways.

Main Methods:

  • Literature review of cell and molecular biology studies.
  • Analysis of research on polyphenol effects on key inflammatory mediators.

Main Results:

  • Most studies focus on polyphenol antioxidant effects on nuclear factor-kappaB (NF-κB), inducible nitric oxide synthase (iNOS), and cyclooxygenase (COX).
  • Polyphenols may modulate inflammatory responses by interacting with multiple steps in the inflammatory cascade.
  • Emerging research links polyphenol action to advanced glycation end product (AGE) formation, hyperglycemia, and oxidative stress.

Conclusions:

  • Polyphenols demonstrate potential in controlling oxidative stress and subsequent inflammatory responses.
  • Clinical trials investigating specific polyphenols are essential to validate their therapeutic efficacy.