An update on cyclooxygenase-2 expression and metabolites in the kidney

This review highlights recent studies examining the expression and function of cyclooxygenase-2 and its metabolites in the kidney.

Expression of cyclooxygenase-2 is regulated by both physiologic and pathophysiologic perturbations, with volume depletion upregulating macula-densa expression and volume expansion upregulating medullary expression. Macula densa cyclooxygenase-2 is a modulator of juxtaglomerular renin expression, and there is increasing evidence that cyclooxygenase-2 expression is modulated by multiple components of the renin-angiotensin system, including angiotensin II, through both AT1 and AT2 receptors. There are also indications that macula densa cyclooxygenase-2 expression may be regulated by the prorenin/renin receptor. Medullary cyclooxygenase-2 metabolites modulate salt and water excretion, and cyclooxygenase-2 inhibitors lead to sodium and volume retention and may raise blood pressure. There is also increasing evidence that cyclooxygenase-2 expression increases in progressive renal injury. Given their cardiovascular and renal side effects, cyclooxygenase-2 inhibitors are not a feasible intervention for long-term therapy against progressive renal damage, but further delineation of the downstream receptors and synthases involved may provide therapeutic targets.

Recent studies have highlighted the important role that cyclooxygenase-2 metabolites play both in regulation of normal renal function and as potential mediators of acute and chronic renal injury.