Related Experiment Video
Updated: Jul 9, 2026

Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
Emphysematous pyelonephritis presenting as gastroenteritis
1Nephrology and Dialysis Center, Department of Medicine, Renal Division, Coney Island Hospital, Brooklyn, New York, USA. goodkidneys@aol.com
Abstract:
Emphysematous pyelonephritis (EPN) is a serious and often life-threatening condition due to a gas-producing and necrotizing infection involving the renal parenchyma and perirenal tissue. The infection is almost exclusively seen in diabetic patients, and the main feature of its presence is finding gas within the kidney. Patients usually present with fever, chills, flank pain, and dysuria. Laboratory testing usually reveals hyperglycemia, leukocytosis, pyuria, an elevated blood urea nitrogen (BUN) level, and high serum creatinine level. Other, nonspecific symptoms such as abdominal pain, nausea, vomiting, and diarrhea can accompany acute pyelonephritis, as found in the reported case. The appropriate management of such serious infection requires combined medical and surgical treatment. In severe infection, nephrectomy should not be delayed. We report a case of EPN in a diabetic patient who presented with gastrointestinal symptoms. A high index of suspicion, coupled with a good imaging study [preferably computed tomography (CT) scanning] of the abdomen can lead to early diagnosis. Appropriate medical and surgical management have resulted in a successful outcome.
Related Concept Videos
Acute Pyelonephritis I: Introduction
Bacterial Gastroenteritis
Acute Pyelonephritis II: Diagnostic Studies and Management
Giardiasis
Amebiasis
Urinary Tract Infection II: Pathophysiology
