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Updated: Jul 9, 2026
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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endophthalmitis associated with intravenous drug use
Kian Keyashian1, Preeti N Malani
1Department of Internal Medicine, Divisions of Infectious Diseases and Geriatric Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA.
Southern Medical Journal
|December 20, 2007
Summary
Intravenous drug use can lead to serious infections like endogenous endophthalmitis. Prompt diagnosis and treatment, including antifungal therapy and potential vitrectomy, are crucial for visual preservation.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Toxicology
Background:
- Intravenous (IV) drug use is associated with significant infectious complications, contributing to morbidity and mortality.
- Endogenous endophthalmitis is a severe intraocular infection that can arise from hematogenous spread.
Observation:
- A case of endogenous endophthalmitis is presented, stemming from the injection of cocaine adulterated with lemon juice.
- This highlights a unique and potentially underreported route of infection in the context of recreational drug use.
Findings:
- The clinical presentation underscores the importance of considering infectious endophthalmitis in IV drug users experiencing visual disturbances.
- Empirical antifungal therapy is recommended during the initial workup for suspected cases.
Implications:
- Clinicians must maintain a high index of suspicion for endogenous endophthalmitis in patients with a history of IV drug use presenting with visual changes.
- Early diagnosis and intervention, including consideration for early vitrectomy, are critical for optimizing visual outcomes and preventing vision loss.
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