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Updated: Jul 9, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts

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Published on: December 22, 2015

Bone block allograft impregnated with bone marrow aspirate.

Muna Soltan¹, Dennis Smiler, Hari S Prasad

¹soltandds@aol.com

Implant Dentistry

|December 20, 2007

Summary

Bone marrow aspirate combined with allograft bone blocks promotes new bone formation for osseous defect repair. This cell-based therapy offers a less invasive, cost-effective alternative to autogenous bone grafting.

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Published on: August 13, 2017

Area of Science:

Regenerative Medicine
Biomaterials Science
Oral and Maxillofacial Surgery

Background:

Bone marrow aspirate (BMA) combined with particulate allografts and xenografts promotes new bone growth.
Allograft bone blocks offer clinical advantages in specific situations.
This study explores cell-based therapy using BMA-derived stem cells within allograft corticocancellous bone blocks for bone regeneration.

Observation:

A technique was developed to combine BMA with block allografts for osseous defect repair.
Five patients with atrophic maxillary and mandibular ridges received grafts using allograft bone blocks saturated with BMA.
Histologic and histomorphometric analysis of a bone core taken 4 months post-implantation was performed.

Findings:

Grafts integrated into recipient bone within 4 to 8 months in all cases.
Implants placed at all 5 grafted sites achieved successful osseointegration.
Histomorphometric analysis revealed the graft comprised 54% bone and 46% marrow, with 89% of the bone being vital.

Implications:

Impregnating allograft bone blocks with BMA stimulates endogenous bone formation.
BMA aspiration is a minimally invasive technique compared to autogenous bone harvesting.
This approach provides predictable results and is cost-effective for bone regeneration.