Effect of sesame oil against acetaminophen-induced acute oxidative hepatic damage in rats
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Published on: November 27, 2019
Victor Raj Mohan Chandrasekaran1, Chang-Hsin Wan, Li-Lian Liu
1Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan, Taiwan.
Abstract:
Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans and experimental animals. We investigated the effect of sesame oil on APAP-induced acute liver injury. Male Wistar rats were given APAP (1,000 mg/kg; orally) to induce acute liver injury. Acetaminophen significantly increased aspartate transaminase, alanine transaminase, lipid peroxidation, and superoxide anion and hydroxyl radical generation levels; it also induced glutathione depletion. Sesame oil (8 mL/kg; orally) did not alter the gastric absorption of APAP, but it inhibited all the parameters altered by APAP and protected the rats against APAP-induced acute liver injury. We hypothesize that sesame oil maintained the intracellular glutathione levels, reduced reactive oxygen species levels, and inhibited lipid peroxidation in rats with APAP-induced acute liver injury.
