Acinetobacter pneumonia: a review

Joshua D Hartzell1, Andrew S Kim, Mark G Kortepeter

  • 1Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. Joshua.Hartzell@na.amedd.army.mil

Insights

Acinetobacter species cause serious hospital infections and are increasingly resistant to antibiotics. Treatment now often relies on older drugs like polymyxins (colistin).

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Acinetobacter species are a growing cause of nosocomial infections.
  • These include hospital-acquired pneumonia and ventilator-associated pneumonia.
  • Increasing antibiotic resistance in Acinetobacter poses a significant treatment challenge.

Purpose of the Study:

  • To review the epidemiology of Acinetobacter infections.
  • To discuss current treatment strategies for Acinetobacter infections.
  • To outline prevention methods for Acinetobacter infections.

Main Methods:

  • Literature review of epidemiology.
  • Analysis of treatment options.
  • Summary of prevention guidelines.

Main Results:

  • Acinetobacter is a significant nosocomial pathogen.
  • Antibiotic resistance is a major concern.
  • Polymyxins (colistin) are often used for treatment.

Conclusions:

  • Effective management requires understanding epidemiology.
  • Treatment relies on older antibiotics due to resistance.
  • Prevention strategies are crucial to control spread.

Related Concept Videos

Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include: