Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscle macrophage regenerative response after squalene-adjuvanted influenza vaccination is associated with type II-skewed response and is reduced with age.

NPJ vaccines·2026
Same author

Highly robust molecular information carriers for traceability of plastic materials.

Nature communications·2026
Same author

POLY-Senolytic nanoplatform for tumor-specific eradication of senescent tumor cells and mitigation of radiotherapy-induced immune resistance of cancer.

Nature communications·2026
Same author

Tailoring fully biobased optical adhesives <i>via</i> hydrogen-bonding modulation.

RSC applied polymers·2026
Same author

Spatiotemporal Nanotransformers for Antitumoral Orchestration of Protein Homeostasis.

Polymer science & technology (Washington, D.C.)·2026
Same author

Multivalent Antibody-Recruiting Molecules for Targeted Immune-Killing of Carbonic Anhydrase IX-Expressing Cancer Cells.

Angewandte Chemie (International ed. in English)·2026

Related Experiment Video

Updated: Jul 9, 2026

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion
08:53

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion

Published on: January 30, 2018

Biodegradable microcapsules designed via 'click' chemistry.

Bruno G De Geest1, Wim Van Camp, Filip E Du Prez

  • 1Department of Pharmaceutics, Utrecht University, 3584 CA Utrecht, The Netherlands. br.degeest@ugent.be

Chemical Communications (Cambridge, England)
|December 20, 2007
PubMed
Summary
This summary is machine-generated.

Modified dextrans form degradable microcapsules using a click reaction. These biocompatible microcapsules are formed via hydrolysable carbonate esters and triazole cross-links, enabling controlled degradation.

More Related Videos

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Extraction of Plant-based Capsules for Microencapsulation Applications
10:54

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Related Experiment Videos

Last Updated: Jul 9, 2026

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion
08:53

Synthesizing Sodium Tungstate and Sodium Molybdate Microcapsules via Bacterial Mineral Excretion

Published on: January 30, 2018

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Extraction of Plant-based Capsules for Microencapsulation Applications
10:54

Extraction of Plant-based Capsules for Microencapsulation Applications

Published on: November 9, 2016

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Dextrans are versatile polysaccharides with potential in biomedical applications.
  • Developing degradable materials is crucial for minimizing environmental impact and improving biocompatibility.
  • Click chemistry offers efficient and specific conjugation methods for material synthesis.

Purpose of the Study:

  • To synthesize novel degradable dextran-based microcapsules.
  • To utilize click chemistry for cross-linking dextran chains.
  • To create a platform for controlled release applications.

Main Methods:

  • Dextran modification with alkyne and azide functionalities via hydrolysable carbonate esters.
  • Formation of microcapsules through copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click reaction.
  • Characterization of microcapsule structure and degradation properties.

Main Results:

  • Successfully synthesized alkyne- and azide-modified dextrans.
  • Formed stable microcapsules through triazole cross-linking via click chemistry.
  • Demonstrated hydrolytic degradability of the microcapsules due to the carbonate ester linkages.

Conclusions:

  • Dextran-based microcapsules can be efficiently formed using click chemistry.
  • The hydrolysable carbonate ester linkages ensure the degradability of the microcapsules.
  • These degradable microcapsules show promise for various biomedical and drug delivery applications.