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Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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Related Experiment Video

Updated: Jul 9, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Coronary slow-flow phenomenon.

Louis C Paul¹, Dinesh Jani, Alda Menete

¹Instituto do Coraç ão de Maputo, Mozambique.

Cardiovascular Journal of Africa

|December 20, 2007

Summary

Slow contrast flow in coronary arteries, a common angiography finding, can rarely progress to severe no-flow or TIMI, posing life-threatening risks. This case highlights slow flow in a patient

Area of Science:

Cardiology
Interventional Cardiology
Diagnostic Imaging

Background:

Slow contrast flow in normal coronary arteries is a recognized finding during coronary angiography.
The most severe manifestation, no-flow or Thrombolysis In Myocardial Infarction (TIMI) grade 0-1 flow, is rare but clinically significant.

Observation:

A case of slow flow was observed in the left anterior descending artery.
The patient was undergoing a routine diagnostic coronary angiogram.

Findings:

The case presented slow contrast perfusion in a major coronary artery.
This finding, while common in its mild form, can represent a spectrum of coronary flow abnormalities.

Implications:

Understanding the spectrum of slow flow is crucial for accurate angiographic interpretation.

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Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

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Last Updated: Jul 9, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

Prompt recognition and management of severe slow flow or no-flow phenomena are essential to prevent adverse cardiac events.