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Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
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Published on: August 24, 2019

Reduced exercise capacity in systemic sclerosis patients without pulmonary involvement.

N C de Oliveira1, L M dos Santos Sabbag, L M Ueno

  • 1Rheumatology Division, University of Sao Paulo, Brazil. reumato@usp.br

Scandinavian Journal of Rheumatology
|December 20, 2007
PubMed
Summary

Women with systemic sclerosis (SSc) without lung issues show reduced exercise capacity. This may stem from abnormal vascular responses during physical exertion in SSc patients.

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Cardiopulmonary Exercise Testing
  • Rheumatology
  • Vascular Physiology

Background:

  • Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vascular dysfunction and fibrosis.
  • Pulmonary involvement is common in SSc, but exercise capacity in patients without overt lung disease is less understood.

Purpose of the Study:

  • To assess the exercise capacity of women with SSc and no pulmonary involvement.
  • To compare cardiopulmonary stress test parameters between SSc patients and healthy controls.

Main Methods:

  • A maximum cardiopulmonary stress test (Bruce protocol) was performed on 13 female SSc patients and 13 age- and BMI-matched healthy female controls.
  • Key parameters analyzed included peak oxygen uptake (VO2peak), anaerobic threshold (AT), respiratory compensation point (RCP), and metabolic equivalent (MET).

Main Results:

  • SSc patients exhibited significantly reduced VO2peak (19.8 vs. 23.7 mL/kg/min) and MET at peak exercise (5.6 vs. 6.7 MET) compared to controls (p=0.04).
  • A shorter time interval between AT and RCP was observed in SSc patients (112.6 vs. 164.0 s, p=0.03).
  • Forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO) were within normal limits in SSc patients.

Conclusions:

  • Systemic sclerosis patients without pulmonary impairment demonstrate diminished exercise capacity.
  • Abnormal vascular response during exercise is a potential contributing factor to reduced exercise capacity in SSc.