Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sequence-specific, dynamic covalent crosslinking in aqueous media.

Minfeng Li1, Kazuhiro Yamato, Joseph S Ferguson

  • 1Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, New York 14260, USA.

Journal of the American Chemical Society
|December 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Divergent molecular mechanisms underlie differential toxicity of trivalent lanthanum and divalent cadmium in Enchytraeus crypticus.

Ecotoxicology and environmental safety·2026
Same author

NF-κB p65 modulates the promoter activity of large yellow croaker (Larimichthys crocea) interleukin-2.

Developmental and comparative immunology·2026
Same author

Unraveling the Mechanism of Perillyl Alcohol and Its Derivatives as Potent Antifungal Agents against Gray Mold.

Journal of agricultural and food chemistry·2026
Same author

GLP-1RA Liraglutide Attenuates Sepsis by Modulating Gut Microbiota and Associated Metabolites.

Nutrients·2026
Same author

Structural and mechanistic insights into caseinolytic protease inhibition for antimicrobial development against Pseudomonas plecoglossicida.

PLoS pathogens·2026
Same author

Liquiritigenin-loaded poly (acrylic acid)-carboxymethyl cellulose hydrogels: formulation optimization, performance evaluation, and assessment of therapeutic efficacy for wound healing and sepsis caused by wound bacterial infection.

Frontiers in bioengineering and biotechnology·2026
Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026
Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026
Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026
Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026
Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026
Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026
See all related articles

This study presents a novel system combining hydrogen bonding and dynamic covalent interactions for highly specific molecular assembly. This approach enables sequence-specific crosslinking of oligoamides in various media, paving the way for advanced material construction.

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Organic Chemistry

Background:

  • Designing molecular systems with high specificity and stability is crucial for advanced applications.
  • Traditional methods often face limitations in achieving both high fidelity and robustness in diverse environments.

Purpose of the Study:

  • To develop and characterize a novel associating system integrating hydrogen bonding and dynamic covalent interactions.
  • To demonstrate sequence-specific crosslinking of oligoamides with high fidelity and stability.

Main Methods:

  • Modification of linear oligoamides with S-trityl groups for disulfide bond formation.
  • Analysis of disulfide-crosslinking reactions using ESI, MALDI-TOF, HPLC, and 2D NMR.
  • Systematic probing of the crosslinking mechanism to determine thermodynamic control.

Related Experiment Videos

Main Results:

  • Achieved sequence-specific crosslinking of complementary oligoamides in both nonpolar and aqueous media.
  • Demonstrated high fidelity of multiply hydrogen-bonded assemblies combined with covalent interaction stability.
  • Observed length-dependent selectivity, preventing crosslinking of mismatched oligoamide lengths or sequences.

Conclusions:

  • The developed system successfully integrates hydrogen bonding and dynamic covalent interactions for robust and specific molecular association.
  • As few as two hydrogen bonds are sufficient to direct specific crosslinking in aqueous media.
  • This strategy offers a generalizable approach for designing tunable, stable, and highly specific molecular associating units for diverse applications.