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Related Concept Videos

Cleavage and Blastulation01:33

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Uterus and Cervix01:18

Uterus and Cervix

The uterus, commonly called the womb, is a vital reproductive organ in females designed to provide a nurturing environment for the implantation and growth of an embryo. It is shaped like a hollow pear and positioned between the urinary bladder and the rectum. The uterus's structure allows it to support and protect a developing fetus throughout pregnancy.
The uterus is securely anchored within the pelvic cavity by paired broad ligaments on either side. It is further stabilized by three pairs of...
Histology of the Uterus01:19

Histology of the Uterus

The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
Uterine Tubes01:16

Uterine Tubes

The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
Proliferative Phase01:20

Proliferative Phase

The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
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Related Experiment Video

Updated: Jul 9, 2026

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae
07:37

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

Endometrial stromal nodule embedded into term placenta.

Eva F Karpf1, Bernhard Poetsch, Cord Langner

  • 1Institute of Pathology, Medical University of Graz, Graz, Austria. eva.karpf@meduni-graz.at

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|December 21, 2007
PubMed
Summary

A benign endometrial stromal nodule was found at the uteroplacental interface during pregnancy. Hormonal influences during gestation likely caused its unusual growth and increased proliferation.

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Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
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Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

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Last Updated: Jul 9, 2026

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae
07:37

Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae

Published on: April 30, 2018

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
12:40

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

Area of Science:

  • Gynecologic Pathology
  • Reproductive Endocrinology
  • Obstetrics

Background:

  • Endometrial stromal tumors are rare neoplasms arising from the uterine stroma.
  • Pregnancy can influence the behavior and morphology of uterine lesions.
  • Early diagnosis and characterization of uterine tumors during pregnancy are crucial.

Observation:

  • A 28-year-old pregnant patient at 28 weeks gestation presented with an asymptomatic 5 cm tumor at the uteroplacental interface.
  • The tumor was ultrasonographically detected and appeared attached to the decidua.
  • Post-delivery, the tumor was found embedded within the placenta.

Findings:

  • Microscopic examination revealed features of an endometrial stromal tumor with a high mitotic rate.
  • Immunohistochemistry showed positivity for CD10 and progesterone receptors.
  • The tumor exhibited an expansile, non-infiltrative pushing border with decidualization and myxoid changes.

Implications:

  • The findings suggest a benign endometrial stromal nodule with pregnancy-induced changes.
  • Hormonal stimulation during pregnancy may lead to increased proliferation and unusual morphology.
  • This case highlights the importance of considering pregnancy-related hormonal effects in the interpretation of uterine neoplasms.