Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spatial analysis and surname analysis: complementary tools for shedding light on human longevity patterns.

A Montesanto1, G Passarino, A Senatore

  • 1Department of Cell Biology, University of Calabria. 87036 Rende, Italy.

Annals of Human Genetics
|December 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Institutionalising forensic sciences and medicine in centres for newly arrived unaccompanied minors: A case study from Milano.

Journal of forensic and legal medicine·2021
Same author

Single neuron serotonin receptor subtype gene expression correlates with behaviour within and across three molluscan species.

Proceedings. Biological sciences·2018
Same author

miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth.

Blood cancer journal·2016
Same author

The Standard Model from LHC to future colliders.

The European physical journal. C, Particles and fields·2015
Same author

Air pollution monitoring using emission inventories combined with the moss bag approach.

The Science of the total environment·2015
Same author

Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity.

Pflugers Archiv : European journal of physiology·2014
Same journal

Utility of Urine-Derived Cells for Characterizing Aberrant Splicing Caused by a Novel Deep Intronic L1CAM Variant.

Annals of human genetics·2026
Same journal

Distribution of HLA-DRB1 Alleles and Genotypes With Respect to Plasma Anti-SARS-CoV-2 IgG Titres Among COVID-19-Vaccinated Bangladeshi Adults.

Annals of human genetics·2026
Same journal

FIGLA Novel Variant c.385-9G>A Affects RNA Splicing in a Minigene Assay.

Annals of human genetics·2026
Same journal

Epigenetic Shifts in MTNR1A, MTNR1B and Fn14 and Their Links to Preeclampsia Risk.

Annals of human genetics·2026
Same journal

Hip Bone Marrow Adiposity as a Risk Factor for Alzheimer's Disease: Insights From Mendelian Randomization Analysis.

Annals of human genetics·2026
Same journal

A Novel Biallelic REL Frameshift Variant p.(Tyr9Ilefs*2) Causing Immunodeficiency-92 With Profound c-Rel Deficiency.

Annals of human genetics·2026
See all related articles

Human longevity varies by region, influenced by population genetics. Spatial and surname analyses in Calabria revealed isolated zones with high longevity and inbreeding, particularly in males.

Area of Science:

  • Demography
  • Population Genetics
  • Spatial Analysis

Background:

  • Human longevity exhibits significant regional variations.
  • Geographic features can create population isolates, impacting genetic structure.
  • Understanding these factors is crucial for public health and demographic studies.

Purpose of the Study:

  • To investigate the influence of population genetic structure on regional longevity patterns.
  • To identify geographical zones with exceptional longevity in Calabria, Italy.
  • To correlate genetic isolation with longevity using spatial and surname analyses.

Main Methods:

  • Spatial Analysis utilizing Geographic Information System (GIS) to map longevity hotspots.
  • Surname analysis (Fisher's alpha) to assess population genetic structure and inbreeding levels.

Related Experiment Videos

  • Correlation analysis between surname abundance, longevity index, and geographical isolation.

    • Main Results:

    • Identified three distinct zones of high longevity in Calabria: two near Cosenza and one isolated mountainous area in southern Calabria.
    • The isolated southern zone showed the lowest Female/Male ratio among nonagenarians.
    • A significant negative correlation was found between surname abundance and longevity index, indicating high inbreeding in the isolated zone.

    Conclusions:

    • Spatial analysis is effective in identifying geographical longevity patterns.
    • Population genetic structure, including inbreeding in isolated areas, significantly shapes longevity patterns.
    • The study highlights the interplay between geography, genetics, and human lifespan.