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Updated: Jul 9, 2026

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy
06:38

High Sensitivity Measurement of Transcription Factor-DNA Binding Affinities by Competitive Titration Using Fluorescence Microscopy

Published on: February 7, 2019

Effective transcription factor binding site prediction using a combination of optimization, a genetic algorithm and

Victor G Levitsky1, Elena V Ignatieva, Elena A Ananko

  • 1Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russia. levitsky@bionet.nsc.ru

BMC Bioinformatics
|December 21, 2007
PubMed
Summary

This study introduces SiteGA, a novel method to improve transcription factor binding site (TFBS) prediction by analyzing sequence interactions. Combining SiteGA with optimized Position Weight Matrix (PWM) algorithms significantly reduces false positives in genome analysis.

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