Related Experiment Video
Updated: Jul 9, 2026

In vitro Measurements of Tracheal Constriction Using Mice
Published on: June 25, 2012
Regulation of heterotrimeric G protein signaling in airway smooth muscle
Raymond B Penn1, Jeffrey L Benovic
1Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. rpenn@wfubmc.edu
Abstract:
Heterotrimeric G proteins transduce signals from G protein-coupled receptors to regulate numerous signaling events and functions in airway smooth muscle (ASM). In this article, we detail the function and regulation of heterotrimeric G protein signaling in ASM. We further discuss recent advances in the development of experimental tools in the study of G protein signaling, and speculate how these tools might be used in therapeutic strategies that seek to mitigate bronchospasm and airway remodeling that occur in obstructive airway disease.
Related Concept Videos
GPCRs Regulate Adenylyl Cylase Activity
Two...
Activation and Inactivation of G Proteins
Nitric Oxide Signaling Pathway
GTPases and their Regulation
Large G-proteins, also known...
GTPases and their Regulation
Large G-proteins, also known...
G-Protein Gated Ion Channels
Sensory organs,...

