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Molecular Profiling of the Invasive Tumor Microenvironment in a 3-Dimensional Model of Colorectal Cancer Cells and Ex vivo Fibroblasts
Published on: April 29, 2014
Colorectal carcinoma: in vitro evaluation with high-spatial-resolution 3D constructive interference in steady-state
Ichiro Yamada1, Satoshi Okabe, Masayuki Enomoto
1Department of Diagnostic Radiology and Oncology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Radiology
|December 21, 2007
Summary
High-spatial-resolution 3D CISS MR imaging accurately evaluates colorectal carcinoma mural invasion and macroscopic features in vitro. This technique shows high diagnostic accuracy, aiding in surgical planning and patient management.
Area of Science:
- Radiology
- Oncology
- Gastroenterology
Background:
- Colorectal carcinoma (CRC) poses a significant health challenge.
- Accurate assessment of mural invasion is crucial for staging and treatment.
- In vitro imaging techniques are vital for detailed pathological analysis.
Purpose of the Study:
- To evaluate the diagnostic accuracy of high-spatial-resolution 3D CISS MR imaging.
- To assess the in vitro mural invasion and macroscopic features of colorectal carcinomas.
- To compare 3D CISS MR imaging with histopathologic and macroscopic findings.
Main Methods:
- Retrospective analysis of prospectively obtained in vitro MR images.
- Utilized 1.5-T MR system with high-spatial-resolution 3D CISS sequences.
- Compared 3D CISS MR images and virtual MR endoscopic images with histopathology and macroscopic findings.
Main Results:
- 3D CISS MR imaging showed high correlation with histopathologic staging of mural invasion (r = 0.976).
- Diagnostic accuracy for mural invasion was 98%-100%, with 100% sensitivity.
- Virtual MR endoscopy accurately depicted macroscopic features in 95% of cases (r = 0.916).
Conclusions:
- High-spatial-resolution 3D CISS MR imaging is a highly accurate tool for in vitro evaluation of CRC.
- The technique effectively assesses mural invasion and macroscopic characteristics.
- This MR imaging modality holds promise for detailed preoperative assessment of colorectal tumors.
