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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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Flow behaviour of a POSS biopolymer solution.

Asmeret G Kidane1, Mohan J Edirisinghe, Philipp Bonhoeffer

  • 1Biomaterial and Tissue Engineering Centre, Academic Division of Surgical & Interventional Sciences, University College London, London, UK.

Biorheology
|December 21, 2007
PubMed
Summary

A novel polyhedral oligomeric silsesquioxane (POSS) nanocomposite biopolymer shows promising rheological properties for medical applications. This POSS-biopolymer exhibits near-Newtonian behavior and stable viscosity, making it suitable for tissue engineering and medical devices.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Science

Background:

  • Development of advanced biopolymers is crucial for fabricating medical devices and tissue engineering.
  • Polyhedral oligomeric silsesquioxane (POSS) nanocomposites offer unique material properties.
  • Conventional polymers like polycarbonate urethane (PCU) have limitations in specific biomedical applications.

Purpose of the Study:

  • To synthesize and characterize a novel non-biodegradable POSS nanocomposite biopolymer.
  • To investigate the rheological properties of the POSS-biopolymer solution for potential biomedical applications.
  • To compare the performance of the POSS-biopolymer with conventional polycarbonate urethane (PCU).

Main Methods:

  • Synthesis of a 2 wt% POSS nanocomposite biopolymer solution.
  • Rheological characterization including shear stress and viscosity measurements as a function of shear rate at ambient temperature.
  • Investigation of temperature dependence of viscosity and the effect of ageing on viscosity.
  • Estimation of yield stress and pseudoplasticity index.

Main Results:

  • The POSS-PCU polymer solution demonstrated near-Newtonian behavior up to 1000 s(-1) shear rate.
  • Apparent viscosity was approximately 3000 mPa s with a pseudoplasticity index of 0.90, slightly decreasing with 9 months of ageing.
  • The POSS polymer solution exhibited very low temperature dependence of viscosity, which remained stable with ageing.
  • Yield strength increased from 2.7 Pa to 8.3 Pa upon ageing.

Conclusions:

  • The developed POSS nanocomposite biopolymer possesses favorable rheological characteristics for medical device fabrication and tissue engineering.
  • Its near-Newtonian behavior, stable viscosity, and low temperature dependence indicate suitability for demanding biomedical applications.
  • The observed increase in yield strength with ageing suggests potential for enhanced structural integrity in aged applications.