Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis I: Introduction

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Arterial human blood flow can be stopped by cables of VWF and platelets without coagulation.

Blood advances·2025

Same author

Development of a novel point-of-care device to monitor arterial thrombosis.

Lab on a chip·2025

Same author

Advancing microfluidic point-of-care platelet function tests: opportunities and challenges from bench to market.

Frontiers in bioengineering and biotechnology·2024

Same author

PneumoniaCheck, a novel aerosol collection device, permits capture of airborne Mycobacterium tuberculosis and characterisation of the cough aeromicrobiome in people with tuberculosis.

Annals of clinical microbiology and antimicrobials·2024

Same author

Detection of pathogenic bacteria and biomarkers in lung specimens from cystic fibrosis patients.

Journal of breath research·2024

Same author

Material strengths of shear-induced platelet aggregation clots and coagulation clots.

Scientific reports·2024

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Development of a flow-through system to create occluding thrombus.

David N Ku¹, Conor J Flannery

¹GWW School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332-0405, USA. david.ku@me.gatech.edu

|December 21, 2007

Summary

This study introduces a novel flow-through system for rapidly inducing and visualizing occlusive thrombosis under arterial flow conditions. The system enables real-time monitoring of thrombus formation, aiding in the development of new anti-thrombotic therapies.

More Related Videos

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model

Published on: April 19, 2024

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Published on: July 19, 2016

Related Experiment Videos

Last Updated: Jul 9, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model

Tracking Fibrinolysis of Chandler Loop-Formed Whole Blood Clots Under Shear Flow in An In-Vitro Thrombolysis Model

Published on: April 19, 2024

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Published on: July 19, 2016

Area of Science:

Biomedical Engineering
Cardiovascular Research
Thrombosis Modeling

Background:

Occlusive thrombosis is a major cause of heart attacks and strokes.
Current animal models for thrombosis research have limitations in predicting therapeutic efficacy due to species-specific responses.
Developing reliable in vitro methods for studying thrombosis is crucial for advancing anti-thrombotic drug development.

Purpose of the Study:

To present a new flow-through system for rapid occlusive thrombosis induction under arterial flow.
To enable real-time visualization and characterization of thrombus formation and progression.
To establish a reliable platform for evaluating anti-thrombotic therapies.

Main Methods:

Perfusing whole porcine blood through a tubular test section under controlled arterial flow conditions.
Real-time visualization of thrombus development, from initial platelet adhesion to complete occlusion.
Monitoring flow rate reduction to differentiate thrombus formation from embolization.

Main Results:

The system successfully induced rapid occlusive thrombosis in a flow-through setup.
Thrombus growth rate was observed to be a linear function of high shear rates (>40,000 s(-1)).
Histological analysis showed predominantly platelet accumulation, forming a rough surface with tendrils.

Conclusions:

The developed flow-through system effectively models arterial occlusive thrombosis.
This platform offers a valuable tool for the economic and efficient testing of novel anti-thrombotic agents.
The system's ability to visualize thrombus progression in real-time enhances understanding of thrombotic events.