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Tetanus01:29

Tetanus

Tetanus is a life-threatening neurological disorder characterized by persistent muscle contractions and spastic paralysis. It is caused by Clostridium tetani, a motile, Gram-positive, rod-shaped, obligate anaerobe. These bacteria produce terminal endospores, giving them a distinctive “lollipop” or “tennis-racket” appearance. They thrive in anaerobic environments, such as those found in deep puncture wounds.Once introduced into the body, the spores germinate into vegetative cells. These cells...

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Related Experiment Video

Updated: Jul 9, 2026

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
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[Evaluation of SD BIOLINE tetanus kit].

Jee-Eun Lee1, Soo-Youn Lee

  • 1Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The Korean Journal of Laboratory Medicine
|December 21, 2007
PubMed
Summary

The SD BIOLINE tetanus kit offers excellent analytical performance for evaluating tetanus immunization status at the point-of-care. This rapid test demonstrates high accuracy and ease of use, making it suitable for emergency departments.

Area of Science:

  • Immunology
  • Clinical Diagnostics
  • Point-of-Care Testing

Background:

  • Point-of-care-testing (POCT) is crucial in emergency departments for assessing tetanus immunization status.
  • Evaluating the analytical performance of POCT kits is essential for reliable patient management.

Purpose of the Study:

  • To evaluate the analytical performance and clinical utility of the SD BIOLINE tetanus kit as a POCT device.
  • To assess the accuracy, precision, and processing time of the SD BIOLINE tetanus kit.

Main Methods:

  • Analyzed 326 peripheral blood specimens (whole blood and serum) from healthy subjects and patients.
  • Evaluated the SD BIOLINE tetanus kit for precision, accuracy, specimen effects, operator variance, and processing time.
  • Compared results with two quantitative ELISA kits.

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Main Results:

  • The SD BIOLINE tetanus kit demonstrated high sensitivity (88-97%) and specificity (87-92%) compared to ELISA.
  • Achieved excellent precision, high accuracy, and strong concordance between whole blood and serum specimens.
  • Reported a total processing time of 30-40 minutes.

Conclusions:

  • The SD BIOLINE tetanus kit exhibits excellent analytical performance for tetanus antibody testing.
  • Its rapid turnaround time, ease of handling, and interpretation make it suitable for POCT.
  • Emphasized the need for operator education and standardized interpretation guidelines for optimal use.