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Changes in vitamin D after gastrectomy.
Yasushi Rino1, Yuji Yamamoto, Nobuyuki Wada
1Department of Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Summary
This study found that gastrectomy patients often have lower levels of vitamin D metabolites 25(OH) vitamin D3 and 24,25(OH)(2) vitamin D3. This suggests gastrectomy moderately impacts vitamin D metabolism, potentially affecting bone health.
Area of Science:
- Endocrinology
- Nutritional Science
- Gastroenterology
Background:
- Previous research indicated 1alpha hydroxy vitamin D3 is effective for post-gastrectomy bone disorders.
- This study aimed to gather further evidence on 1alpha hydroxy vitamin D3's efficacy in these patients.
Purpose of the Study:
- To investigate the impact of gastrectomy on vitamin D metabolism.
- To assess the levels of various vitamin D metabolites in post-gastrectomy patients.
Main Methods:
- 22 outpatients post-gastrectomy (gastric cancer) were analyzed.
- Blood tests measured: 1,25(OH)(2) vitamin D3, 25(OH) vitamin D3, 24,25(OH)(2) vitamin D3, calcium, phosphorus, alkaline phosphatase, PTH, and osteocalcin.
Main Results:
- While 1,25(OH)(2) vitamin D3 levels were normal, 31.8% had low 25(OH) vitamin D3 and 86.4% had low 24,25(OH)(2) vitamin D3.
- Lower 25(OH) vitamin D3 levels were associated with longer time post-surgery and total gastrectomy.
- No factors were identified correlating with the decrease in 25(OH) vitamin D3 and 24,25(OH)(2) vitamin D3.
Conclusions:
- Gastrectomy moderately influences vitamin D metabolism, specifically decreasing 25(OH) vitamin D3 and 24,25(OH)(2) vitamin D3 levels.
- A homeostatic mechanism appears to maintain normal 1,25(OH)(2) vitamin D3 levels, crucial for calcium regulation.
- Further research is needed to identify factors contributing to the observed decrease in specific vitamin D metabolites.
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