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12:48
Isolation and Analysis of Brain-sequestered Leukocytes from Plasmodium berghei ANKA-infected Mice
Published on: January 2, 2013
[Cerebellar malacias in younger patients]
K Urbánek1, J Bartosek, I Vlachová
1Neurologická klinika LF UP, Olomouc.
Ceskoslovenska Neurologie a Neurochirurgie
|September 1, 1991
Summary
Cerebellar malacia in middle-aged adults presents with severe headaches and neurological deficits. Arteriospasms may be the cause, highlighting the need for prompt treatment including calcium antagonists.
Area of Science:
- Neurology
- Pathology
Background:
- Cerebellar malacia is a rare condition affecting the cerebellum.
- Understanding its pathogenesis is crucial for timely diagnosis and treatment.
Observation:
- Four patients aged 40-45 years with cerebellar malacia were studied.
- Clinical presentation included severe occipital headache, nausea, vomiting, and focal neurological deficits after a latency period.
Findings:
- No advanced arteriosclerosis or hypertension was noted; some had prior arteriospastic conditions like migraine or angina pectoris.
- CT scans revealed bilateral cerebellar malacia in most cases.
- Necropsy in one fatal case showed extensive cerebellar lesions with normal vasculature.
Implications:
- Arteriospasms are suggested as a key pathogenetic factor in young to middle-aged individuals.
- Secondary edema significantly impacts prognosis.
- Combined therapy with vasoactive and antiedematous agents, including calcium antagonists, is recommended.
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