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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Sigmund Freud's psychosexual theory of development suggests that early childhood experiences significantly shape personality and behavior. Freud proposed that development is discontinuous, occurring in five distinct stages, each defined by a focus on different erogenous zones. He believed that failure to resolve the conflicts specific to each stage successfully could result in fixation, potentially influencing behavior as adults.
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Conduct disorder is a complex mental health diagnosis characterized by a repetitive and persistent pattern of behavior that violates societal norms, the rights of others, or age-appropriate rules. The diagnostic criteria for conduct disorder require the presence of at least three problematic behaviors within the past 12 months, with at least one occurring in the past six months. These behaviors are grouped into four categories: aggression toward people and animals; destruction of property;...
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Related Experiment Video

Updated: Jul 9, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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Published on: November 21, 2013

The developmental origins of conversion disorders.

Kasia Kozlowska1

  • 1University of Sydney, Australia. kasiak@chw.edu.au

Clinical Child Psychology and Psychiatry
|December 22, 2007
PubMed
Summary

Attachment theory reveals conversion disorder stems from two innate animal defense behaviors: freeze and appeasement. Understanding these distinct developmental pathways is crucial for tailored treatments in children.

Area of Science:

  • Developmental Psychology
  • Neuroscience
  • Clinical Psychology

Background:

  • Attachment theory provides a framework for understanding conversion reactions.
  • Conversion symptoms may originate from innate animal defense behaviors: freeze and appeasement.
  • These behaviors are linked to distinct neurobiological mechanisms and developmental pathways.

Purpose of the Study:

  • To explore the phylogenetic roots of conversion reactions through attachment theory.
  • To identify two distinct developmental pathways for conversion disorder.
  • To differentiate treatment approaches based on these pathways.

Main Methods:

  • Utilizing attachment theory as a developmental framework.
  • Analyzing innate animal defense behaviors (freeze and appeasement) in relation to conversion symptoms.

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Published on: January 9, 2015

  • Examining context-dependent developmental experiences and their neurobiological underpinnings.
  • Main Results:

    • Conversion reactions are linked to two distinct, threat-elicited emotional responses rooted in animal defense behaviors.
    • Pathway 1 involves freeze response components, inhibition of negative affect, and caregiver punishment.
    • Pathway 2 involves appeasement behaviors and unpredictable parental actions threatening safety or health.

    Conclusions:

    • Children with conversion disorder are not a homogenous group.
    • Two distinct functional groups exist, each requiring different therapeutic interventions.
    • Attachment theory offers a novel perspective for understanding and treating conversion disorders.