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A Luciferase-fluorescent Reporter Influenza Virus for Live Imaging and Quantification of Viral Infection
Published on: August 14, 2019
[Influenza in children]
1Université Claude-Bernard-Lyon-1, Service d'urgence et de réanimation pédiatrique, hôpital Edouard-Herriot, Lyon. daniel.floret@chu-lyon.fr
Insights
Influenza significantly impacts children, especially infants under one year, posing risks comparable to elderly adults. Early diagnosis and appropriate treatment, avoiding aspirin, are crucial for managing pediatric influenza.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Influenza disproportionately affects children, serving as a primary community transmission source.
- Infants under one year, particularly those under six months, face hospitalization risks equivalent to high-risk adult populations.
- Pre-existing conditions like asthma and chronic diseases elevate influenza severity in children.
Purpose of the Study:
- To highlight the significant burden of influenza in pediatric populations.
- To delineate the specific risks and clinical manifestations of influenza in young children.
- To provide guidance on diagnosis, treatment, and prevention strategies for pediatric influenza.
Main Methods:
- Review of recent epidemiological data on pediatric influenza.
- Analysis of clinical presentations and risk factors in affected children.
- Evaluation of current diagnostic tools and therapeutic options for influenza in children.
Main Results:
- Children, especially infants, are a major demographic for influenza infection and community spread.
- Influenza in young children often presents with non-specific respiratory and non-respiratory symptoms.
- Rapid diagnostic tests are available, and treatment focuses on fever management, avoiding aspirin, and judicious antibiotic use.
Conclusions:
- Influenza poses a substantial threat to infants and young children, necessitating targeted public health and clinical attention.
- Antiviral medications like oseltamivir and zanamivir are indicated for treatment and prophylaxis in children over one and five years, respectively.
- Effective management involves prompt diagnosis, symptomatic care, and appropriate antiviral therapy, while avoiding aspirin due to Reye syndrome risk.
Abstract:
It has been recently demonstrated that influenza is not predominantly an adult disease but affects massively the children and spreads to the community from them. Affected children may be admitted to hospital and the maximal risk concerns those younger than 1 year and mainly <6 months of age. For them, the risk to be admitted is equivalent to that observed in elderly and adults with underlying conditions. Asthma and chronic diseases enhance the risk in children in the same proportions as observed in adults. Influenza may lead to death, infants aged 0-6 months being the most affected. Young children with influenza exhibit a non specific respiratory illness and often non respiratory manifestations (isolated fever, GI tract illness, convulsions). Influenza rapid "doctor tests" are now available and may be used at the physician's surgery. Treating fever is the most important purpose. Aspirin use should be avoided due to an increased risk of Reye syndrome. Antibiotic prescription is not indicated, except in case of bacterial super infection. Neuraminidase inhibitors may be used for treatment of influenza in children from 1 year (oseltamivir) or 5 years (zanamivir). These medications may also be used for prophylaxis of the disease.
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Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Drug Dosing: Infants and Children
Viral Meningitis

