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Published on: October 6, 2023
Construction and validation of an automated flow hydrogenation instrument for application in high-throughput organic
Bruce Clapham1, Noel S Wilson, Melissa J Michmerhuizen
1High-Throughput Organic Synthesis and Automation Engineering, Department of Advanced Technology, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA. bruce.clapham@abbott.com
Abstract:
This manuscript details the construction of a fully automated flow hydrogenation apparatus for use in high-throughput organic synthesis. The instrument comprises of a Bohdan robot platform coupled with a ThalesNano H-cube hydrogenator and a series of solvent valves and pumping mechanisms. Using this instrument, we have been able to fully automate a number of key transformations that could not otherwise be conveniently undertaken in a high-throughput manner.
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