Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Novel Predictive Tool for Poor Anticoagulation Control in Patients on Vitamin K Antagonists in Spain: An Exploratory Study.

Journal of clinical medicine·2026
Same author

Selection of standards for measuring patient-reported outcomes in cardiology departments of the Spanish National Health System (PROMCAR 1).

Revista espanola de cardiologia (English ed.)·2026
Same author

Prevalence and persistence of suboptimal anticoagulation control with vitamin K antagonists in Spain.

Revista espanola de cardiologia (English ed.)·2026
Same author

Regional inequalities in heart failure hospitalisation and in-hospital mortality in Spain (2016-2022): a nationwide, observational study.

The Lancet regional health. Europe·2025
Same author

Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design.

Frontiers in cardiovascular medicine·2025
Same author

Perception and knowledge of CVD among women in Spain: national survey on awareness, risk, and lifestyle.

Revista espanola de cardiologia (English ed.)·2025

Related Experiment Video

Updated: Jul 9, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Ezetimibe plus simvastatin cardiovascular outcomes study program.

Luis Rodríguez Padial1

  • 1Cardiac Unit, Hospital Virgen de la Salud, Avda. Barber, 30, 45004 Toledo, Spain. lrodriguez@sescam.org

Expert Review of Cardiovascular Therapy
|December 22, 2007
PubMed
Summary

Ezetimibe, when added to statins, significantly lowers low-density lipoprotein-cholesterol by 18-20%. Ongoing trials will determine its impact on high-risk cardiovascular disease patients.

Related Experiment Videos

Last Updated: Jul 9, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Ezetimibe effectively reduces blood cholesterol by inhibiting intestinal absorption.
  • When combined with statins, ezetimibe offers an additional 18-20% reduction in low-density lipoprotein-cholesterol.
  • This combination counters statin-induced compensatory increases in cholesterol absorption.

Purpose of the Study:

  • To evaluate the impact of ezetimibe plus simvastatin in high-risk patient populations.
  • To assess the efficacy of this combination therapy in diverse cardiovascular conditions.

Main Methods:

  • Four major outcome trials are currently investigating ezetimibe plus simvastatin.
  • Studies focus on specific patient subsets including familiar hypercholesterolemia, degenerative aortic stenosis, chronic kidney disease, and acute coronary syndrome.

Main Results:

  • Ezetimibe plus simvastatin demonstrates a significant additional reduction in low-density lipoprotein-cholesterol.
  • The combination therapy addresses compensatory cholesterol absorption increases associated with statin use.

Conclusions:

  • Ezetimibe in combination with statins provides a potent strategy for lowering LDL-C.
  • Future trial data will elucidate the role of this combination in reducing cardiovascular disease burden in high-risk individuals.