Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients
Georg Juckel1, Yehonala Gudlowski, Dirk Müller
1Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Germany. george.juckel@wkp-lwl.org
Abstract:
Serotonergic dysfunction appears to be involved in the pathogenesis of schizophrenia. The loudness dependence of auditory evoked potentials (LDAEP) has been suggested to be a valid indicator of the brain serotonin system's activity in humans. Patients with schizophrenia showed weaker LDAEP, indicating high serotonergic activity, in comparison to healthy controls. Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia.
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