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Updated: Jul 9, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Celiac disease diagnosed in the elderly.

Yoav Lurie¹, Dan-Avi Landau, Jorge Pfeffer

¹Liver Disease Unit, Gastroenterology Institue, Tel-Aviv Sorasky Medical Center, Tel Aviv, Israel. dr_lurie@tasmc.health.gov.il

Journal of Clinical Gastroenterology

|December 22, 2007

Summary

Celiac disease (CD) is often diagnosed late in elderly patients, presenting with diverse symptoms like anemia and neurological issues. Early diagnosis and a gluten-free diet significantly improve outcomes for older adults with CD.

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Last Updated: Jul 9, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Area of Science:

Gastroenterology
Geriatrics
Immunology

Background:

Celiac disease (CD) diagnosis is increasing in adults, including the elderly.
CD often presents with varied manifestations, leading to underdiagnosis in older populations.
This study focuses on a case series of CD diagnosed after age 60.

Observation:

Seven elderly patients diagnosed with CD after age 60 were identified.
Common symptoms included weight loss, iron deficiency anemia, and diarrhea.
Other manifestations involved osteoporosis, elevated liver enzymes, and neurological issues like cognitive decline and neuropathy.

Findings:

A median diagnostic delay of 8 years was observed.
Gluten-free diet led to symptom resolution and weight gain in most patients.
One patient developed fatal intestinal T-cell lymphoma, highlighting potential complications.

Implications:

CD should be considered in elderly patients with unexplained symptoms.
Prompt diagnosis and treatment are crucial for improving health outcomes in older adults with CD.
Increased awareness can reduce diagnostic delays and associated morbidity.