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Blood is thicker than lymph.

¹Department of Medicine and University of Pennsylvania Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. markkahn@mail.med.upenn.edu

The Journal of Clinical Investigation

|December 22, 2007

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Loss of adrenomedullin peptide signaling causes embryonic death due to defects in blood and lymphatic vessel development. These findings reveal a novel angiogenic pathway and highlight vascular biology's intricate relationships.

Area of Science:

Vascular biology
Developmental biology
Molecular signaling

Background:

Vessel growth is crucial for embryonic development and diseases like cancer.
Signaling pathways regulating vessel growth and function are not fully understood.
Adrenomedullin peptide signaling's role in vascular development was previously unclear.

Discussion:

Two studies identify adrenomedullin as critical for embryonic vascular development.
Loss of adrenomedullin signaling leads to embryonic edema and lethality.
Phenotypes are linked to defects in either lymphatic or blood vessels, suggesting complex roles.

Key Insights:

Adrenomedullin signaling is essential for both blood and lymphatic vessel integrity.
This research defines a novel angiogenic signaling pathway.

Related Experiment Videos

The studies underscore the interconnectedness of blood and lymphatic systems.

Outlook:

Further research into adrenomedullin's role in vascular diseases is warranted.
Understanding these intricate relationships is key for therapeutic strategies.
Investigating the molecular mechanisms linking adrenomedullin to vessel development is crucial.