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The effects of relative humidity and super-disintegrant concentrations on the mechanical properties of pharmaceutical
Christine Hersen-Delesalle1, Bernard Leclerc, Guy Couarraze
1Faculté de Pharmacie, Université Paris, Paris, France.
Abstract:
The influence of the composition and the relative humidity on the properties of pharmaceutical compacts prepared from mixtures of three excipients and three super-disintegrants was evaluated. Various amounts of super-disintegrant and different conditions of relative humidity during the storage were used to study mechanistically the disintegration process and to connect it to compact's mechanical properties. Three point single beam test was used to measure tensile strength and Young's modulus of compacts containing various amount of disintegrant and stored under various relative humidity. The presence of moisture within pharmaceutical compacts containing a disintegrant influences drastically their mechanical properties. Then, the results are related to micro-cracks visualized by MEB.
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