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The relationship between age of asthma onset and cardiovascular disease in Canadians
Shilpa Dogra1, Chris I Ardern, Joseph Baker
1Lifespan Health and Performance Laboratory. shilpad@yorku.ca
Insights
Asthma patients have a significantly higher risk of heart disease and high blood pressure. The age of asthma onset did not influence this increased cardiovascular disease risk in Canadian adults.
Area of Science:
- Cardiology
- Pulmonology
- Epidemiology
Background:
- Asthma is a chronic respiratory condition.
- Cardiovascular disease (CVD) poses a significant health burden.
- The relationship between asthma and CVD requires further investigation.
Purpose of the Study:
- To quantify the association between asthma and cardiovascular disease (CVD) in Canadian adults.
- To investigate if the age of asthma onset moderates the asthma-CVD relationship.
Main Methods:
- Utilized data from 74,342 Canadian adults from the Canadian Community Health Survey.
- Categorized asthma onset into early-onset (0-20 years) and adult-onset (21-54 years).
- Assessed CVD outcomes including high blood pressure, heart disease, and stroke.
Main Results:
- Asthmatics showed a 43% increased likelihood of heart disease (OR=1.43).
- Asthmatics demonstrated a 36% increased likelihood of high blood pressure (OR=1.36).
- No significant moderation effect of asthma onset age on CVD outcomes was observed.
Conclusions:
- Confirmed a positive association between asthma and cardiovascular disease in Canadian adults.
- Age of asthma onset does not appear to modify the increased risk of CVD in asthmatics.
- Future research should explore asthma severity and phenotypes in relation to CVD.
Purpose:
To quantify the association between cardiovascular disease (CVD) and asthma in Canadian adults and to determine whether age of asthma onset is a moderator of this association.
Methods:
We used a sample of 74 342 participants with a mean age of 56.4 +/- 12.5 from cycle 1.1 of the Canadian Community Health Survey. Asthma age of onset was categorized into early-onset (0-20 years) and adult-onset (21-54 years). Three major outcomes were used to estimate the relationship between asthma and CVD, namely: high blood pressure, heart disease, and stroke.
Results:
Multiple logistic regression models revealed that asthmatics were 43% (OR = 1.43, CI = 1.19-1.72) more likely to have heart disease, and 36% (OR = 1.36, CI = 1.21-1.53) more likely to have high blood pressure than non-asthmatics. There were no consistent results for age of onset with high blood pressure, heart disease, or stroke.
Conclusion:
Using a population-based dataset we confirmed that asthmatics are at increased odds of cardiovascular disease compared to non-asthmatics; furthermore, age of asthma onset did not appear to moderate this relationship. Future research should focus on determining whether asthma severity or allergic/non-allergic phenotypes have a differential effect on the asthma-CVD relationship.
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