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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model

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Pregnancy following infertility: a concern?

R Chibber¹, M H Al-Sibai

¹Department of Obstetrics and Gynecology, College of Medicine, King Faisal University, Dammam, Kingdom of Saudi Arabia. rachana_chibber@yahoo.co.uk

Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology

|December 22, 2007

Summary

Women experiencing a waiting time to pregnancy (WTP) over one year, especially those treated for infertility, face increased risks. This includes higher rates of preterm birth and C-section for first-time mothers, impacting neonatal intensive care unit admissions.

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Fertility Preservation in Patients with Severe Ovarian Dysfunction

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Published on: March 25, 2021

Area of Science:

Reproductive Medicine
Maternal-Fetal Medicine
Perinatology

Background:

A waiting time to pregnancy (WTP) exceeding one year is common.
Understanding its impact on pregnancy outcomes is crucial for maternal and neonatal health.
Infertility treatments may influence these outcomes.

Purpose of the Study:

To assess if a WTP >1 year increases adverse pregnancy outcomes in healthy women.
To compare outcomes between women conceiving spontaneously versus after infertility treatment.
To identify specific risks associated with delayed conception.

Main Methods:

Retrospective analysis of 992 pregnancies with WTP >1 year.
Comparison between women treated for infertility (Group A) and those conceiving spontaneously (Group B).
Subgroup analysis of primigravidae (first-time mothers) in both groups (A1 and B1).

Main Results:

Primigravidae with WTP >1 year showed a significant increased risk of preterm birth (34-37 weeks).
Women treated for infertility (Group A1) had shorter gestations, lower birth weights, and higher NICU admission rates compared to untreated primigravidae (Group B1).
Primigravidae in the treated group had a statistically significant higher risk of cesarean births.

Conclusions:

Delayed conception (>1 year), particularly with infertility treatment, is associated with adverse pregnancy outcomes in primigravidae.
These outcomes include increased preterm birth, lower birth weight, and higher rates of C-sections.
Further research is warranted to explore mechanisms and interventions for mitigating these risks.