Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Selective intestinal decontamination--yes or no?].

F Daschner1, K Geiger

  • 1Klinikhygiene, Universitätsklinikum Freiburg.

Klinische Wochenschrift
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring HIV disease indicators at MDR-TB treatment initiation in South Africa.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2024
Same author

Generalist palliative care for non-cancer patients : A review article.

Schmerz (Berlin, Germany)·2016
Same author

[Generalist palliative care for non-cancer patients: A review article].

Schmerz (Berlin, Germany)·2015
Same author

Development and validation of an alternative disturbed skin model by mechanical abrasion to study drug penetration.

Results in pharma sciences·2015
Same author

Prognostic Value of Conventional Magnetic Resonance Imaging for Adult Patients with Brain Tumors.

Clinical neuroradiology·2014
Same author

Obituary Prof. Dr. Walter Marget.

Infection·2013
Same journal

Klinische Wochenschrift·2020
Same journal

Pathological anatomy of malnutrition.

Klinische Wochenschrift·2010
Same journal

Consequences of chronic malnutrition in the clinical picture of internal diseases.

Klinische Wochenschrift·2010
Same journal

Use of stable isotopes in biology.

Klinische Wochenschrift·2010
Same journal

About applications of radioactive indicators in medicine and physiology.

Klinische Wochenschrift·2010
Same journal

Early diagnosis and assessment of the activity of pulmonary tuberculosis based on serological examinations.

Klinische Wochenschrift·2010
See all related articles

Selective digestive decontamination (SDD) reduces gram-negative pneumonia but may increase gram-positive infections. Mortality benefits are unclear, and SDD can drive antibiotic resistance, questioning its broad use.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Context:

  • Selective digestive decontamination (SDD) is used in mechanically ventilated patients to prevent pneumonia.
  • While SDD reduces gram-negative bacterial pneumonia, concerns exist regarding increased gram-positive infections.

Purpose:

  • To evaluate the efficacy and safety of selective digestive decontamination (SDD) in preventing pneumonia in artificial ventilation.
  • To assess the impact of SDD on bacterial resistance and patient mortality.

Summary:

  • SDD reduces gram-negative pneumonia incidence but may increase gram-positive pneumonia.
  • Current evidence does not consistently show a reduction in mortality with SDD.
  • SDD use is linked to the development of resistance in gram-negative bacteria and specific gram-positive organisms like oxacillin-resistant staphylococci.

Related Experiment Videos

Impact:

  • The emergence of antibiotic resistance necessitates further research into optimal antibiotic strategies and hygiene measures.
  • Broad, non-selective application of SDD, particularly in intensive care units, is not currently justified.
  • Future multicenter, randomized, prospective double-blind studies are required to define appropriate antibiotic use and preventive strategies against resistance and colonization.