Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HIV infection of the adult thymus: an even more conventional theory explaining CD4 cell decrease and CD8 cell

P J Harris1, P D Candeloro, J E Bunn

  • 1AIDS Clinical Research Center, Washington, DC 20009.

Medical Hypotheses
|December 1, 1991
PubMed
Summary

Human Immunodeficiency Virus (HIV) infection causes a decrease in CD4 T-cells and an increase in CD8 T-cells. This study proposes a new explanation for this immune system change, challenging the idea that HIV directly kills CD4 cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Post-Anthesis High-Temperature Stress on Carbon Partitioning and Starch Biosynthesis in a Spring Wheat (Triticum aestivum L.) Adapted to Moderate Growth Temperatures.

Plant & cell physiology·2023
Same author

APICAL INTRUSIVE GROWTH OF FIBRES FROM THE FLOWERING STEM OF LOLIUM TEMULENTUM L.

The New phytologist·2022
Same author

A mathematical model for simulating the spread of a disease through a country divided into geographical regions with different population densities.

Journal of mathematical biology·2022
Same author

Arbuscular mycorrhizal fungi confer enhanced arsenate resistance on Holcus lanatus.

The New phytologist·2021
Same author

Effects of soil phosphorus on spore germination and hyphal growth of arbuscular mycorrhizal fungi.

The New phytologist·2021
Same author

Severe hepatic dysfunction is associated with venous thromboembolic events in phase 1 clinical trials.

Thrombosis research·2015

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • * CD4 T-cell depletion and CD8 T-cell proliferation are hallmark changes in HIV infection.
  • * Current understanding attributes these changes to the direct cytotoxic effects of HIV on CD4 cells.
  • * The precise mechanisms driving these immune alterations require further investigation.

Purpose of the Study:

  • * To propose and explore an alternative hypothesis for the observed CD4 and CD8 T-cell count dynamics in HIV infection.
  • * To challenge the established paradigm of selective CD4 cell killing by HIV.
  • * To offer a novel perspective on HIV pathogenesis and immune dysregulation.

Main Methods:

  • * This study is primarily theoretical, proposing a new model based on existing literature.

Related Experiment Videos

  • * Analysis of immunological data and viral kinetics in the context of HIV infection.
  • * Comparative assessment of proposed mechanisms against established theories.

    • Main Results:

    • * The proposed alternative explanation offers a potential mechanism for CD4 T-cell reduction and CD8 T-cell increase.
    • * This model suggests indirect mechanisms rather than direct viral killing as the primary driver.
    • * The findings provide a new framework for understanding HIV-induced immune changes.

    Conclusions:

    • * The observed CD4 and CD8 T-cell changes in HIV infection may not solely result from direct HIV-induced CD4 cell death.
    • * An alternative explanation involving complex immune interactions is proposed.
    • * Further research is warranted to validate this alternative hypothesis and its implications for HIV treatment.