[Induction of spermatogenesis in hypogonadotropic hypogonadism using pulsatile administration of LHRH]

In male patients with hypogonadotropic hypogonadism development of the testicles may be brought about by means of pulsatile administration of LHRH. The results in 29 treated patients are described. The treatment lasted 53 weeks on average and in all patients led to a rise of the plasma levels of LH, FSH and testosterone, and to an increased testicular volume. Spermatogenesis started in 22 patients. The LHRH treatment induces the secretion of gonadotrophins and consequently, testicular steroidogenesis. This causes virilization to begin. Furthermore, under the influence of the FSH in particular, the tubules and spermatogenesis develop. Fertility may then be achieved. It is concluded that pulsatile LHRH treatment is a suitable method to induce development of the testicles, including spermatogenesis. Once spermatogenesis is initiated, HCG treatment can maintain and even improve this development.