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Characteristic changes on brain CT in a case of Leigh encephalopathy with deficiency of pyruvate dehydrogenase
1Division of Child Neurology, Kibou-no-Ie Rehabilitation Center Hospital for the Handicapped, Gunma, Japan.
Brain & Development
|November 1, 1991
Abstract:
A girl aged 23 months of Leigh encephalopathy with pyruvate dehydrogenase complex (PDHC) deficiency was reported. Brain CT scan showed atrophy of the frontal and parietal cortex, low density in the midbrain and putamina, and rounded caudatum. CT change was showed from rounded to atrophic caudatum during a three-month period. The rounded caudatum may be an early CT finding in Leigh encephalopathy.