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Updated: Sep 12, 2026

The Spared Nerve Injury (SNI) Model of Induced Mechanical Allodynia in Mice
Published on: August 18, 2011
Inherited propensity for neuropathic pain is mediated by sensitivity to injury discharge
1Department of Anaesthesiology, Hadassah University Hospital, Mount Scopus, Israel.
Abstract:
We reported previously that injury discharge (ID), a burst of impulses fired following nerve injury, plays a role in triggering autotomy, a neuropathic pain-related behavior in rats. Here we affirm this link using two lines of rats, derived by selective breeding from the Sabra strain to express high (HA) or low (LA) levels of autotomy following hindpaw denervation. Blocking ID in HA rats before injury suppressed autotomy. Correspondingly, artificial prolongation of ID in LA rats just prior to neurectomy, increased autotomy. The autotomy in these HA and LA rats was like that of their Sabra ancestors. This suggests that the underlying basis for selection of these lines was differential sensitivity of the CNS to the effects of ID.
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