Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell surface glycoconjugates in intercellular and cell-substratum interactions.

S J Rosenman1, W M Gallatin

  • 1ICOS Corporation, Bothell, WA 98021.

Seminars in Cancer Biology
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of treatment on serum levels of soluble intercellular adhesion molecules and tumour necrosis factor-receptor 1 in psoriasis.

The British journal of dermatology·2002
Same author

Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.

Journal of medicinal chemistry·2001
Same author

Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.

Journal of medicinal chemistry·2001
Same author

Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion.

The Journal of cell biology·2000
Same author

Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18.

European journal of immunology·2000
Same author

The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1.

Journal of immunology (Baltimore, Md. : 1950)·1999
Same journal

Unveiling tumor heterogeneity by single cell RNA-sequencing: From basic considerations to clinical applications.

Seminars in cancer biology·2026
Same journal

Hidden architecture of resistance: The extracellular matrix in melanoma's immune landscape.

Seminars in cancer biology·2026
Same journal

Microfluidic technologies for extracellular vesicle isolation and analysis: Implications for translational applications in cancer therapy.

Seminars in cancer biology·2026
Same journal

Exploring glioblastoma microenvironment using organoids: opportunities, limitations, and emerging concepts.

Seminars in cancer biology·2026
Same journal

Special issue: Lipid metabolic alterations in cancer: Pathogenic mechanisms, therapies and common pathophysiology with cardiovascular disease.

Seminars in cancer biology·2026
Same journal

Systemic lipid metabolic alterations and the tumor microenvironment: A hidden driver of immune dysfunction.

Seminars in cancer biology·2026
See all related articles

This study reviews how carbohydrate structures on cell adhesion molecules and extracellular matrix glycoproteins influence cell interactions. Understanding these glycoconjugates is key to deciphering cell-cell and cell-substratum adhesion dynamics.

Area of Science:

  • Glycobiology
  • Cell Biology
  • Biochemistry

Background:

  • Cell surface adhesion molecules and extracellular matrix glycoproteins play critical roles in biological processes.
  • The carbohydrate moieties (glycans) of these molecules are increasingly recognized as important functional components.
  • Alterations in glycosylation patterns are often associated with cellular changes, including those seen in cancer.

Purpose of the Study:

  • To evaluate the current understanding of the functional roles of carbohydrate structures in cell adhesion.
  • To examine the involvement of glycoconjugates in cell-cell and cell-substratum interactions.
  • To highlight specific examples where the structures of functionally important glycans have been elucidated.

Main Methods:

  • Literature review and synthesis of existing research findings.

Related Experiment Videos

  • Analysis of case studies focusing on specific cell adhesion systems.
  • Examination of data linking glycosylation changes to altered cell adhesive behavior.

    • Main Results:

    • Carbohydrate structures on cell adhesion molecules significantly modulate cell adhesive functions.
    • Oligosaccharides on extracellular matrix glycoproteins are integral to cell-matrix interactions.
    • Specific examples demonstrate the direct correlation between determined glycan structures and adhesion mechanisms.

    Conclusions:

    • Glycans are crucial regulators of cell adhesion, impacting both cell-cell and cell-substratum interactions.
    • Further structural determination of functionally important glycans will enhance our understanding of cell adhesion.
    • Transformation-associated changes in glycosylation offer insights into disease mechanisms and potential therapeutic targets.