[An experimental study of the antidepressive properties of captopril]

Captopril, as well as amitriptyline, was shown to enhance apomorphine-induced stereotype in mice. At doses, which failed to modify the effect of apomorphine, both substances reversed the inhibitory action of sulpiride and haloperidol on stereotypical behaviour. Treatment with captopril (25 mg/kg) did not modify the open-field behaviour, but significantly reduced the immobility in the forced swim test (20 mg/kg) Dopaminergic link was suggested to be involved in the CNS effect of captopril.