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IMC bovine pericardial valve: 11 years
D M Braile1, R V Ardito, O T Greco
1Department of Cardiovascular Surgery, Instituto de Moléstias Cardiovasculares, Sao Jose do Rio Preto, Brazil.
Journal of Cardiac Surgery
|December 1, 1991
Summary
This study evaluated bovine pericardial valves in mitral positions, finding comparable long-term survival rates for adults and youngsters. Bovine pericardial valves demonstrated a 95% freedom from fatal complications, indicating their safety and efficacy in mitral valve replacement.
Area of Science:
- Cardiovascular Surgery
- Biomaterials Science
- Clinical Outcomes Research
Background:
- Bovine pericardial valves have been utilized in cardiac surgery since 1977.
- A significant number of these valves have been implanted, necessitating long-term outcome evaluation.
- Understanding the performance in specific valve positions, like the mitral, is crucial.
Purpose of the Study:
- To assess the long-term efficacy and safety of bovine pericardial valves implanted exclusively in the mitral position.
- To compare outcomes between adult and pediatric patient groups.
- To analyze the incidence of both fatal and non-fatal valve-related complications.
Main Methods:
- Retrospective analysis of 666 mitral valve replacements using bovine pericardial valves from 1977 to 1988.
- Patient cohort divided into adults (>21 years) and youngsters (<21 years).
- Actuarial survival and complication rates (fatal and non-fatal) were calculated over an 11-year follow-up period.
Main Results:
- Hospital mortality was 9.2%, with a trend towards improvement in the later study period (6.3% vs. 13.2%).
- Actuarial survival rates were similar for both groups: 74.3% +/- 6.5% for youngsters and 73.0% +/- 3.7% for adults.
- Freedom from fatal valve-related complications was high at 95.0% +/- 1.0%.
Conclusions:
- Bovine pericardial valves demonstrate acceptable long-term survival and a high degree of safety when used for mitral valve replacement in both adult and pediatric populations.
- The incidence of fatal complications is low, with endocarditis and thromboembolism being the primary concerns.
- Continued monitoring for complications such as calcification and periprosthetic leakage is warranted.