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HLA and venous thrombosis: a prospective study.
E Ivasková1, I Prerovský, M Riedel
1Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
Cor Et Vasa
|January 1, 1991
Summary
This study found a link between venous thrombosis and specific HLA types, particularly HLA Cw4. These findings suggest HLA Cw4 may be a laboratory risk factor for developing venous thrombosis.
Area of Science:
- Immunogenetics
- Thrombosis Research
- Orthopedic Surgery
Background:
- Venous thrombosis is a significant complication after total hip replacement.
- Human Leukocyte Antigen (HLA) typing is crucial in transplantation and has been explored for other disease associations.
Purpose of the Study:
- To investigate the association between HLA antigens and the occurrence of venous thrombosis in patients undergoing total hip replacement.
- To identify potential HLA-related risk factors for postoperative venous thrombosis.
Main Methods:
- Prospective study of 154 patients undergoing total hip replacement.
- Diagnosis of venous thrombosis using fibrinogen uptake test and ultrasound.
- HLA typing performed on all participants.
Main Results:
- An association was observed between venous thrombosis and the presence of HLA Cw4 (34.4%) and HLA B35 (27.3%).
- HLA B35 was in linkage disequilibrium with HLA Cw4.
- Relative risks for Cw4 and B35 were 2.531 and 1.935, respectively.
Conclusions:
- The presence of HLA Cw4 is suggested as a laboratory risk factor for venous thrombosis.
- HLA antigen profiling may offer insights into predicting thrombosis risk in surgical patients.