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Some questions concerning a small, more electronegative LDL circulating in human plasma
P Avogaro1, G Cazzolato, G Bittolo-Bon
1Regional Center for Atherosclerosis, Venice, Italy.
Atherosclerosis
|November 1, 1991
Summary
Atherosclerosis may involve modified low-density lipoprotein (LDL) entering artery walls via scavenger pathways. Small, electronegative LDL particles, possibly from oxidation, may contribute to foam cell formation and disease progression.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Atherosclerosis Research
Background:
- Atherosclerosis is a widespread disease, particularly in Western societies.
- While low-density lipoprotein (LDL) receptor defects are known, they are rare causes.
- The scavenger pathway is implicated in cholesterol entry into the arterial wall, forming foam cells.
Purpose of the Study:
- To explore the role of modified LDL in atherosclerosis.
- To investigate the significance of LDL subfractions in disease pathogenesis.
- To support the hypothesis that electronegative LDL contributes to foam cell formation.
Main Methods:
- Analysis of LDL subfractions in human plasma.
- Comparison of in vitro modified LDL with in vivo observations.
- Review of experimental evidence on LDL modification.
Main Results:
- Two LDL subfractions were identified in human plasma.
- A minor, more electronegative LDL subfraction exhibited traits of modified LDL.
- Evidence suggests LDL modification can occur in vivo within the vascular wall.
Conclusions:
- Small, more electronegative LDL particles may represent modified LDL.
- Oxidative processes are a potential origin for these modified LDL particles.
- Electronegative LDL is hypothesized to play a role in atherosclerosis development.