Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac function in hypothermia.

T Lauri1, M Leskinen, J Timisjärvi

  • 1Department of Physiology, University of Oulu, Finland.

Arctic Medical Research
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nurses' knowledge of radiation protection: A cross-sectional study.

Radiography (London, England : 1995)·2019
Same author

Development and validation of a psychometric scale for assessing healthcare professionals' knowledge in radiation protection.

Radiography (London, England : 1995)·2019
Same author

Follow-up study of the early, randomised paracetamol trial to preterm infants, found no adverse reactions at the two-years corrected age.

Acta paediatrica (Oslo, Norway : 1992)·2018
Same author

Cardiac troponin-I as a screening tool for myocarditis in children hospitalized for viral infection.

Acta paediatrica (Oslo, Norway : 1992)·2009
Same author

Mast cell chymase induces apoptosis of vascular smooth muscle cells.

Arteriosclerosis, thrombosis, and vascular biology·2001
Same author

Doppler radar detection of exceptional mass-migration of aphids into Finland.

International journal of biometeorology·2000
Same journal

Jack Hildes Medal in Circumpolar Health.

Arctic medical research·1996
Same journal

Adverse reactions to N-acetylcysteine in Inuit to paracetamol (acetaminophen) overdose.

Arctic medical research·1996
Same journal

Spondyloarthropathies in circumpolar populations: II. Characterization of the populations.

Arctic medical research·1996
Same journal

Spondyloarthropathies in circumpolar populations: I. Design and methods of United States and Russian studies.

Arctic medical research·1996
Same journal

Seasonal variation in hospital admissions for chronic obstructive pulmonary disease in Finland.

Arctic medical research·1996
Same journal

Polar day and polar night: month of year and time of day and the use of physical and pharmacological restraint in a north Norwegian university psychiatric hospital.

Arctic medical research·1996
See all related articles

Hypothermia significantly slows cardiac relaxation by reducing the speed of ventricular pressure fall. This effect is linked to temperature-dependent calcium kinetics, impacting cardiac output.

Area of Science:

  • Cardiology
  • Physiology
  • Hypothermia Research

Background:

  • Hypothermia affects cardiac function, altering contraction and cycle phases.
  • Understanding cardiac response to cold is crucial for clinical applications.

Purpose of the Study:

  • To investigate the effects of hypothermia on cardiac relaxation dynamics.
  • To explore the relationship between temperature, calcium kinetics, and cardiac output.

Main Methods:

  • Six anesthetized beagle dogs were cooled to 25°C aortic blood temperature.
  • Cardiac function was monitored during cooling and rewarming to normothermia.
  • Ventricular pressure fall and negative dp/dt were measured to assess relaxation speed.

Main Results:

Related Experiment Videos

  • Cardiac relaxation speed was halved during hypothermia, indicated by prolonged time constants and reduced negative dp/dt.
  • Decreased cardiac output was primarily due to reduced stroke volume.
  • Sympathetic tone persisted despite cold narcosis.

Conclusions:

  • Hypothermia significantly retards cardiac relaxation, likely due to altered calcium kinetics.
  • Reduced stroke volume is the main driver of decreased cardiac output under hypothermia.
  • Cardiac sympathetic activity remains present even in cold narcosis.