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4-Diazo-5-alkylsulphonamidopyrazoles: synthesis and evaluation of biological activity
C B Vicentini1, A C Veronese, P Giori
1Dipartimento di Scienze Farmaceutiche, Università di Ferrara, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|November 1, 1991
Abstract:
A series of 4-diazo-5-alkylsulphonamidopyrazoles (5) was prepared and tested for antitumor, antiviral and antimicrobial activity. Compounds (5a) and (5b) showed a selective, although not very potent cytostatic activity against L1210 and a human T lymphoblastoid cell line (C8166). Compounds (5a) and (5d-h) showed a selective anti-coxsackie B1 virus activity, whereas 5b was also endowed with some activity against Bacillus subtilis.