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Modulation of cholinergic profile of acetylcholine through its cyclovinylogues
R M Gaion1, A M Grion, P Montanari
1Dipartimento di Farmacologia E. Meneghetti, Università di Padova, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|November 1, 1991
Abstract:
The o-, m- and p-acetoxymethyl-N,N,N-trimethylbenzenemethanaminium iodide (2a-c) as cyclovinilogues of acetylcholine are described. This structural modification allows to modulate the cholinergic activity of the natural neurotransmitter along the sequence: agonist----partial agonist----antagonist, which is referred to meta (2b), para (2c) and ortho (2a) regioisomers, respectively.