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Updated: Aug 19, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
Published on: June 18, 2020
[Pathogenesis and therapy of ascites in liver cirrhosis]
1Klinik und Poliklinik für Innere Medizin Martin-Luther-Universität Halle-Wittenberg.
Abstract:
This paper reviews pathogenetic factors which contribute to the development of therapy-resistant ascites in liver cirrhosis. Main principles are known as "Overfilling"--and "Underfilling"-hypotheses followed by disturbances of different kinds of mediators influencing renal blood flow and natriuresis. The endpoint of a cascade is the development of a hepatorenal syndrome which is connected with therapeutic resistance against diuretics. Therefore, other therapeutic methods (paracentesis, reinfusion) must be taken in to account in order to improve prognosis of such cases.
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