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Related Experiment Videos

Delirium: how its concept has developed.

Z J Lipowski1

  • 1University of Toronto, Canada.

International Psychogeriatrics
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Delirium, a syndrome of disordered consciousness, has evolved over 2,500 years. Early recognition of clinical features and humane management paved the way for understanding its link to reduced brain metabolic rate and EEG changes.

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Area of Science:

  • Neurology
  • Psychiatry
  • Medical History

Background:

  • The concept of delirium has a long history, with core features recognized since the 16th century.
  • Management of delirium has evolved towards a more humane approach since the modern era.
  • In the 19th century, delirium became associated with disordered consciousness and confusion, often in the context of functional mental disorders.

Observation:

  • The 19th century saw significant conceptual shifts in understanding delirium.
  • Key researchers like Engel and Romano proposed that delirium results from a reduced brain metabolic rate.
  • This hypothesis was supported by observed slowing of electroencephalogram (EEG) background activity.

Findings:

  • The article traces the historical development of delirium concepts over 2,500 years.

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  • It highlights the evolution of clinical recognition and management strategies.
  • The link between delirium, disordered consciousness, and reduced brain metabolic rate (evidenced by EEG changes) is a central theme.

    • Implications:

    • Understanding the historical trajectory of delirium research is crucial for current clinical practice.
    • The proposed link to metabolic rate and EEG activity offers a neurobiological basis for the syndrome.
    • Identifying research priorities can guide future investigations into delirium's causes and treatments.