[Changes in basic fibroblast growth factor in lung injury induced by combined injury]

In this study, we have investigated the changes of basic fibroblast growth factor after lung injury. Acute lung injury was produced by combination injury (burn and blast injury). Basic fibroblast growth factor was isolated from lung tissue. Mitogenic activity was determined by measuring the incorporation of 3H-thymidine into DNA by confluent cultures of 3T3 cells. The result revealed that the level of basic fibroblast growth factor was elevated significantly in 1, 3, 5 days after lung injury. On 7th days after injury, the basic fibroblast growth factor was not detected. The findings suggest that basic fibroblast growth factor takes an important role in lung injury and repair. The mechanism of elevation of basic fibroblast growth factor in the lung after injury was discussed.