Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lithium treatment during alcoholic withdrawal.

E M Sellers, S D Cooper, D H Zilm

    Clinical Pharmacology and Therapeutics
    |August 1, 1976
    PubMed
    Summary

    Lithium carbonate effectively reduces withdrawal symptoms and improves motor skills in mild alcoholic withdrawal patients. Early administration while drinking may enhance benefits due to delayed blood concentration plateau.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage.

    Toxicology reports·2021
    Same author

    Alteration in hypoplasia of the hindfoot structures during early growth in clubfeet treated using the Ponseti method.

    Journal of children's orthopaedics·2017
    Same author

    Psilocybin: Good Trip or Bad Trip.

    Clinical pharmacology and therapeutics·2017
    Same author

    Abuse Potential and Pharmacodynamic Characteristics of Oral and Intranasal Eluxadoline, a Mixed μ- and κ-Opioid Receptor Agonist and δ-Opioid Receptor Antagonist.

    The Journal of pharmacology and experimental therapeutics·2016
    Same author

    Deconstructing Designer Drugs.

    Clinical pharmacology and therapeutics·2016
    Same author

    The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting.

    Clinical pharmacology and therapeutics·2016

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Addiction Medicine

    Background:

    • Chronic alcoholism leads to significant withdrawal symptoms.
    • Alcohol withdrawal syndrome (AWS) presents a major clinical challenge.
    • Pharmacological interventions are crucial for managing AWS.

    Purpose of the Study:

    • To evaluate the efficacy of lithium carbonate in managing chronic alcoholic male patients during withdrawal.
    • To assess the impact of lithium carbonate on subjective and objective measures of alcohol withdrawal.

    Main Methods:

    • A study involving 18 male patients with chronic alcoholism undergoing withdrawal.
    • Administration of oral lithium carbonate (0.3 gm every 8 hours).
    • Monitoring of subjective withdrawal symptoms and performance on a motor tracking task.

    Main Results:

    • Lithium carbonate significantly diminished subjective withdrawal symptoms.
    • Oral lithium carbonate normalized performance on a motor tracking task.
    • Lithium administration did not significantly alter catecholamine excretion, vital signs, or other physiological markers.

    Conclusions:

    • Lithium carbonate is a potentially effective treatment for mild alcoholic withdrawal.
    • Initiating lithium treatment earlier, even during continued ethanol consumption, may yield greater benefits.
    • Lithium's mechanism in AWS does not appear to involve significant alterations in catecholamine pathways or key physiological parameters.

    Related Experiment Videos