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Related Experiment Videos

Dextrorphan blocks long- but not short-term memory in a passive avoidance task in rats.

J Sierocinska1, E Nikolaev, W Danysz

  • 1Nencki Institute of Experimental Biology, Warsaw, Poland.

European Journal of Pharmacology
|November 19, 1991
PubMed
Summary

Dextrorphan impaired long-term memory in a passive avoidance task without affecting behavior. This memory effect was similar to NMDA receptor antagonist MK-801, suggesting dextrorphan

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Cognitive Science

Background:

  • Dextrorphan is a mixed sigma and phencyclidine (PCP) site ligand.
  • Understanding the effects of dextrorphan on memory is crucial for cognitive research.

Purpose of the Study:

  • To investigate the effects of dextrorphan on long-term and short-term memory.
  • To determine if dextrorphan's effects are mediated by N-methyl-D-aspartate (NMDA) receptors.

Main Methods:

  • A passive avoidance task was used to assess memory in subjects.
  • Dextrorphan (22 mg/kg) and MK-801 (0.1 mg/kg), a selective NMDA receptor antagonist, were administered.
  • Behavioral alterations that could interfere with performance were monitored.

Main Results:

Related Experiment Videos

  • Dextrorphan significantly blocked long-term memory but not short-term memory.
  • No behavioral changes were observed that could confound the memory task results.
  • MK-801 produced similar memory impairments, supporting the role of NMDA receptors.

Conclusions:

  • Dextrorphan appears to selectively impair long-term memory.
  • The findings suggest that dextrorphan's memory effects are likely mediated through the blockade of NMDA receptors.