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Related Experiment Videos

Changes in pancreatic exocrine secretion with age: pancreatic exocrine secretion does decrease in the elderly.

R Laugier1, J P Bernard, P Berthezene

  • 1Clinique des Maladies de l'Appareil Digestif et de la Nutrition, Hôpital Sainte-Marguerite, Marseille, France.

Digestion
|January 1, 1991
PubMed
Summary
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Pancreatic exocrine function declines with age, showing reduced fluid, bicarbonate, and enzyme secretion after age 30. Calcium concentration increases, potentially explaining some cases of pancreatic insufficiency in older adults.

Area of Science:

  • Gastroenterology
  • Aging Research
  • Physiology

Background:

  • Pancreatic exocrine function is crucial for digestion.
  • Understanding age-related changes in pancreatic secretion is important for diagnosing digestive disorders.

Purpose of the Study:

  • To investigate how pancreatic exocrine secretion parameters change with age in healthy individuals.
  • To establish normative data for pancreatic function across different age groups.

Main Methods:

  • Studied 180 healthy adults aged 16-83 years.
  • Collected duodenal juice after secretin and CCK stimulation.
  • Measured volume, bicarbonate, chloride, calcium, and enzyme (lipase, phospholipase, chymotrypsin) outputs and concentrations.

Main Results:

Related Experiment Videos

  • Fluid and bicarbonate secretion increased until the 3rd decade, then decreased.
  • Enzyme concentrations and outputs linearly decreased with age after the 3rd decade.
  • Calcium concentration increased with age, while chloride output remained unchanged.

Conclusions:

  • Pancreatic exocrine secretion significantly changes with aging.
  • Aging leads to decreased flow rate, bicarbonate, and enzyme secretion, with increased calcium concentration.
  • Age-related decline in pancreatic function may contribute to exocrine insufficiency in some individuals without malnutrition.